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Cleaved-Caspase-9 p10 (D330) Polyclonal Antibody

Cleaved-Caspase-9 p10 (D330) Polyclonal Antibody

簡(jiǎn)要描述:Cleaved-Caspase-9 p10 (D330) Polyclonal Antibody
宿主: Polyclonal, Rabbit,IgG
反應(yīng)性: Human;Rat;Mouse;
應(yīng)用: IF;WB;IHC;ELISA

產(chǎn)品型號(hào): YP-Ab-17668

所屬分類(lèi):多克隆抗體

更新時(shí)間:2024-10-31

詳細(xì)說(shuō)明:

Cleaved-Caspase-9 p10 (D330) Polyclonal Antibody

抗體,也叫免疫球蛋白(Ig),是一種能特異性結(jié)合抗原的糖蛋白,而抗原是在易感染動(dòng)物體內(nèi)引發(fā)抗體產(chǎn)生的物質(zhì)。在體內(nèi),抗體是由于外源性分子的侵襲而產(chǎn)生的。抗體以一個(gè)或者多個(gè)Y字形單體存在,每個(gè)Y字形單體由4條多肽鏈組成,包含兩條相同的重鏈和兩條相同的輕鏈。輕鏈和重鏈?zhǔn)歉鶕?jù)它們的分子量大小來(lái)命名的。Y字形結(jié)構(gòu)的頂端是可變區(qū),為抗原結(jié)合部位。任何一個(gè)抗體的輕鏈都可以分為κ或λ型(基于小分子多肽結(jié)構(gòu)上的差異),每一個(gè)抗體的重鏈則決定了它的類(lèi)或型。






保存溫度:-20℃

產(chǎn)品詳情

Cleaved-Caspase-9 p10 (D330) Polyclonal Antibody detects endogenous levels of fragment of activated Caspase-9 p10 protein resulting from cleavage adjacent to D330.

免疫原詳細(xì)信息

The antiserum was produced against synthesized peptide derived from human Caspase 9. AA range:281-330

相關(guān)試劑

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

背景
CASP9 encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Caspase 9 can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. Caspase 9 is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants


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備注:圖片僅供參考。僅供科研,不可用于臨床。




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